| :: cocaine sensitization |
administration also occur in a stress-induced cocaine sensitization model. These experiments were designed to evaluate whether repeated stress induces
expression of behavioral sensitization to cocaine, the L-type calcium channel antagonist Among cocaine-sensitized animals, the microinjection of KN-93 or
Title : Cocaine-conditioned activity persists for a longer time than cocaine- sensitized activity in mice: Implications for the theories using
Publication » Ceftriaxone prevents the induction of cocaine sensitization and produces enduring attenuation of cue- and cocaine-primed reinstatement of
Title: Effects Of Limbic Sensitization On Self-regard And Psychogenic Symptoms In Cocaine Addicts And Nonusers. Author: Alexander, Deanna. Issue date:
NORADRENERGIC MODULATION OF GLUTAMATE TRANSMISSION IN THE PREFRONTAL CORTEX IN COCAINE SENSITIZATION. uri icon. Overview
Significant sensitization of cocaine-induced stereotyped head movements was evident in animals given 15 or 30 mg/kg chronically in the experimental chamber,
Here, we show that modulated cell signaling in the Drosophila dopamine and serotonin neurons plays an essential role in cocaine sensitization. Targeted
Sensitization to cocaine-induced psychosis was negatively correlated with baseline measures of drug dependence severity and indices of cocaine craving over
Title: Cocaine sensitization in the mouse using a cumulative dosing regime. Author: Elliot, Elizabeth Emily. Citation: Behavioural Pharmacology. 13:407-415
The present study was designed to determine the dose and/or length of exposure to cocaine necessary to induce behavioral sensitization in ovariectomized
Acute cocaine sensitivity and development of behavioral sensitization to the locomotor activating GASP-1 knockout mice exhibit reduced cocaine sensitization.
Early-Life Forebrain Glucocorticoid Receptor Overexpression Increases Anxiety Behavior and Cocaine Sensitization · Biological Psychiatry
In contrast, established cocaine sensitization was markedly Cocaine sensitization involves multiple brain areas related to drug reward and
Contains details of Dopamine receptor antagonists fail prevent induction cocaine sensitization.
Diurnal rhythms in cocaine sensitization and in Period1 levels are common across rodent species. View Full Text (Elsevier ScienceDirect user account required)
Cocaine-induced behavioural sensitization effects are reduced by oleoyl- and palmitoylethanolamide in mice. Autor/es: BLANCO CALVO, EDUARDO; LUQUE
論文：Cocaine sensitization can accelerate the onset of [Pharmacology, biochemistry, and behavior] - Pubmed Result(ATGCchecker)の詳細情報です。
The effects of intra-mPFC SKF 81297 (3 nmol/side) administration on the initiation of behavioral sensitization to cocaine (15 mg/kg i.p.).
motor and neuroendocrine sensitization to cocaine in rats. L. F. Vendruscolo†,‡ and neuroendocrine responses to cocaine sensitization. We used male and
BioInfoBank Library :: Cocaine sensitization does not alter SP
development of sensitization to cocaine in the fruit fly Drosophila melanogaster is strikingly similar sensitized to even a single dose of cocaine whereas others
Measurements of locomotor activity began immediately after saline or cocaine injection and lasted 60 min. Cocaine sensitization. Separate groups of rats were
striatum, alterations in striatal neural activity are hypothesized to play a role in mediating sensitization of cocaine-induced locomotor activity. (Kelly & Iversen
Two-way ANOVA revealed that cocaine sensitization differed significantly for the different genotypes (see text). Further statistical comparisons
This sensitized behavioral response to cocaine was paralleled
Silencing the critics: understanding the effects of cocaine sensitization on dorsolateral and ventral striatum in the context of an actor/critic model. - Maryland .
from repeated administration of cocaine is called cocaine sensitization. This sensitized However, it inhibited the expression of cocaine sensitization during the
Behavioral sensitization to cocaine involves progressive and long-lasting increases in hyperactivity and stereotypy in response to the same daily dose. In order
Yu Liu, Drake Morgan, David Roberts. Psychopharmacology. Abstract Rationale Cross-sensitization between cocaine and amphetamine has been
Kubera M, European journal of pharmacology, Recent studies indicate a role of the immune system in the behavioral effects of cocaine in rodents. In the present
tration also occur in a stress-induced cocaine sensitization model. These experiments have been designed to evaluate whether repeated-immobilization stress
We also tested whether minocycline would affect an already established cocaine sensitization. After establishing the sensitization effect by four
Orphanin Fq And Cocaine Sensitization [Kabirullah Lutfy, University Of California Los Angeles]: Orphanin FQ (OFQ), has been identified as the
of Cocaine Sensitization and Drug Seeking electrophysiology (Henry and White, 1995; Shoji et al.,. 1997). While the accumulating evidence poses reduced
Electrophysiology of behaving rats reveals differential roles for dorsal and ventral prefrontal cortex in cocaine sensitization. Front Cover. Adriana R. Uruena-
Mice exposed to cocaine in utero (40 or 20 mg/kg/day) and controls were given a sensitizing cocaine regimen (15 mg/kg every other day × 7 doses), withdrawn
Sensitization induced by repeated drug exposure has been proposed to increase 'wanting' the drug and.
Reversal of cocaine sensitization-induced behavioral sensitization normalizes GAD67 and GABA(A) receptor alpha 2 subunit expression, and PKC zeta activity
In contrast, intra-mPFC SKF 81297 did not alter the induction or expression of behavioral sensitization to cocaine at the dose tested. In addition, in vivo
We analyzed circadian cocaine sensitization at times when striatal PER1 protein levels in control mice ( naive and sham-pinealectomized) were high and low,
Such commonalities are illustrated by a discussion of cocaine action in the human brain Sensitization and Tolerance to the Motivational and Subjective Effects
The present study was designed to find out whether pharmacological activation of GABA(B) receptors played a role in cocaine sensitization. To this end, male
KAPPA OPIOID AGONISTS AND COCAINE SENSITIZATION. Susan Pickett- schenk, Associate Professor Texas A&m University System 400 Harvey Mitchell
Title: Diurnal rhythms in cocaine sensitization and in Period1 levels are common Using inbred mice, we recently reported that both cocaine sensitization and
sensitization, while pd-GluR1 expression exacerbated cocaine sensitization. Parallel AMPA receptor expression in NAc neurons in cocaine sensitization
Minocycline failed to affect cocaine sensitization in 5-LOX-deficient mice. In these mice, neither cocaine nor minocycline 4-day treatment altered GluR1
Inhibition of cocaine sensitization by MK-801, a noncompetitive N-methyl-D- aspartate (NMDA) receptor antagonist: Evaluation by ambulatory activity in mice
For example, direct electrical stimulation of the PFC leads to rewarding effects and sensitization to cocaine, whereas lesion of the PFC or
Cocaine and other drugs of abuse can alter dopamine function. Such drugs may have Both are examples of the same process, called sensitization. A type of
These changes persist during cocaine withdrawal and may occur in concert with the development of behavioral sensitization. 10:15 a.m. - 10:50 a.m. Changes in
Title: Cocaine sensitization and dopamine mediation of cue effects in rodents, monkeys, and humans: areas of agreement, disagreement, and implications for
Sensitization of the reinforcing effects of cocaine. by Liu, Yu, PhD, WAKE FOREST UNIVERSITY, THE BOWMAN GRAY SCHOOL OF MEDICINE, 2005, 0 pages;
(1999) Andretic et al. Science. Read by researchers in: 91% Biological Sciences, 9% Medicine. The circadian clock consists of a feedback loop in which clock
ulate cocaine sensitization and reward, two phenomena exten- be sively studied in humans and animals because of their importance be for drug abuse.
Reversal of cocaine sensitization-induced behavioral sensitization normalizes GAD67 and GABAA receptor α2 subunit expression, and PKC ζ activity
The present data support the hypothesis that maternal behavior is increased by prior cocaine sensitization, possibly due to cross-sensitization between cocaine
COCAINE. SENSITIZATION. OF SMOOTH. MUSCLE. TO ADRENIN. 187. Cocaine was next added in doses varying from 1 to 10 mgm. (dilutions between
This effect was significantly enhanced by 2 weeks of daily cocaine pretreatment, implicating CRF mechanisms in the CeA in cocaine sensitization as well as in
The initiation of behavioral sensitization to cocaine and other psychomotor stimulants is thought to reflect N-methyl-D-aspartate receptor (NMDAR)-mediated
ulate cocaine sensitization and reward, two phenomena exten- sively studied in that cocaine-induced behavioral sensitization and place preference are under
The increased activity and stereotyped behaviors that result from repeated administration of cocaine is called cocaine sensitization. This sensitized response
To further explore the effects of selective deficits in BDNF-TrkB signaling on cocaine action, we analyzed locomotor activity and sensitization in
Cortical Mechanisms of Cocaine Sensitization. Jeffery D. Steketee Department of Pharmacology, University of Tennessee Health Science Center, Memphis, TN
Cocaine sensitization is produced by repeated exposure to the drug and is thought to reflect neuroadaptations that contribute to addiction. Here
These studies will offer insight into the functional regulation of intracellular mechanisms associated with Group I mGluRs in animals sensitization to cocaine.
The present study determined whether MDMA-induced sensitization to the effects of cocaine could be demonstrated in rats self-administering cocaine.
While sensitization of cocaine's locomotor-activating effects is most commonly studied, sensitization also occurs to its incentive-motivational effects. As is also
To determine whether it is also involved in cocaine sensitization, we measured the p85{alpha}/p110 PI3K activity in the nuclear accumbens
To determine whether it is also involved in cocaine sensitization, we measured the p85α/p110 PI3K activity in the nuclear accumbens (NAc) shell, NAc core, and
several low doses of cocaine (COC) motor behaviors become sensitized to subsequent doses. would also mask the motor effects of cocaine sensitization.
Sensitization to the Locomotor-Stimulating Effect of Cocaine.. 121. METHOD
Sensitized behavioral effects can persist for up to 3 months after cocaine A cross-sensitization between cocaine and the dopamine D2 -like receptor agonist
tyrosine decarboxylase normally seen after cocaine exposure. These findings indicate unexpected roles for these genes in regulating cocaine sensitization and
Unbound MEDLINE/PubMed | Addiction AND cocaine journal
subsequent studies will be necessary to determine the direct cause of this extinction. Incubation of cocaine sensitization and its elimination may have
In the following discussion, the literature on the neurobiology of cocaine sensitization is reviewed in the context of the generation and
Our recent work investigates the role of the NE system in the development of cocaine sensitization, a progressive and lasting enhancement in the motor
Goto and Grace found that, while the cocaine-sensitized rats learned "In this way, the disruption of synaptic plasticity by cocaine sensitization
This dissertation is trying to further characterize cocaine sensitization in females and to examine the role of ascending midbrain dopaminergic system in sex
Title: Effects of minocycline on cocaine sensitization and phosphorylation of GluR1 receptors in 5-lipoxygenase deficient mice. Authors: Chen
induced by dopamine-enhancing drugs like cocaine, as repeated injections of cocaine fail to provoke behav- ioral sensitization in Go2 / mice. In Go2 / mice,
Procedure Experiment 1: One-trial cocaine sensitization In Experiment 1 (N=24), PD 19 rats in the CocaineActivity group were taken to the testing room and
Scheggi S. Behavioral expression of cocaine sensitization in rats is accompanied by a distinct pattern of modifications in the PKA/DARPP-32 signaling pathway.
Psychiatry Research, Volume 175, Issue 1, Pages 165-170, 30 January 2010, Authors:Hye-Jean Park; Feng Ji Cui; Jae Yeon Hwang; Ung Gu
Furthermore, Drosophila develop behavioral sensitization to intermittent doses of cocaine. Sensitization has been linked to the addictive processes in
Unbound MEDLINE/PubMed | Effect of cocaine sensitization prior to pregnancy on maternal care and aggression in the rat. PubMed Journal article. Search
that Alk promotes the development of cocaine sensitization and conditioned exhibit enhanced cocaine sensitization and conditioned place
following repeated treatment, decrease in preening or grooming, persistence following drug withdrawal). Key words: cocaine, sensitization, locomotion, preening
María Vélez Hernández. Physiology Department UPR-Medical Sciences Campus . Wednesday, February 23, 2011 12:00md. Amphitheater 6th
Genomes and Genes, Publications, Research Topics about Cortical Mechanisms of Cocaine Sensitization.
alter acute behavioral responses to cocaine, and they do not block the expression of cocaine sensitization when it is estab- lished before oligonucleotide
ethanol and cocaine. With respect to subsequent cocaine sensitization. the essential feature of prior saline or ethanol treatment appeared to be the handling and
Long-term sensitization in Per mutants. Locomotor responses to acute and repeated saline/cocaine injections in wild-type (wt) mice or mice
Our particular interest is in determining how changes in dopamine transporter ( DAT) function may contribute to cocaine sensitization (Zahniser et al. 1995).
Publication » Integrin-Linked Kinase Is Involved in Cocaine Sensitization by Regulating PSD-95 and Synapsin I Expression and GluR1 Ser(845)
The bilateral removal of ovaries abolished cocaine sensitization. Analogously, human addicts become sensitized to cocaine-induced
development of sensitization to cocaine, indicating that rearrangement of neural . rimonabant does not affect the development of cocaine's sensitization in rats
Pharmacological Regulation of Gene Expression in the CNS: Towards an Understanding of Basal Ganglial Functions (Pharmacology and Toxicology) by
Orphanin FQ and Behavioral Sensitization to Cocaine. Authors: Narayanan S.; Maidment N.T.. Source: Pharmacology Biochemistry and
Cortical circuits involved in cocaine sensitization during withdrawal. Author: Hammer R.P.. Source: Biological Psychiatry, Volume 39, Number 7,
Mechanism of action of cocaine. 2. Behavioral sensitization a. Locomotor b. Rewarding c. Discriminative stimulus. 3. Models of sensitization a. Locomotor b.
In this study, we investigated the role of integrin-linked kinase (ILK) in both the induction and expression of cocaine sensitization. Conditional inhibition of ILK
Unbound MEDLINE/PubMed | Diurnal rhythms in cocaine sensitization and in Period1 levels are common across rodent species. PubMed Journal article
With repeated cocaine use, cocaine conditioned behavior develops to associated stimuli, and in addition, sensitization can occur to the unconditioned stimulant
Our aim is to bring all relevant Specialties in Frontiers | Silencing the critics: understanding the effects of cocaine sensitization on dorsolateral
Context-Specific Reversal of Cocaine Sensitization by the CB1 Cannabinoid Receptor Antagonist Rimonabant. Gregory L Gerdeman1, Jason B
Cocaine sensitization effects were not observed when the cocaine treatments were initiated in a novel environment but were observed when the same cocaine
Cocaine sensitization is correlated to increases in synaptic plasticity and to a “ sensi- Repeated cocaine (COC) administration induces sensitization to its
To test locomotor sensitization to cocaine, on the first two days, mice were Cocaine sensitization was also measured 10 d later (day 17),
The pineal secretory product melatonin decreases cocaine sensitization in rats; mice mutant for the critical melatonin-synthesizing enzyme,
Our study was designed to determine the behavioral effects of testosterone on the development and persistence of cocaine sensitization in
To determine whether it is also involved in cocaine sensitization, we measured the p85 alpha/p110 PI3K activity in the nuclear accumbens (NAc) shell, NAc core
Cocaine sensitization. As shown by McClung and Hirsh [36], repeated exposure to cocaine makes flies increasingly sensitive to the behavioral effects of the drug
Chronic administration of cocaine produces sensitization to its behavioral effects in humans and experimental animals. In the present study, rats treated with
Role For The Calcium/Calmodulin-Stimulated Adenylyl Cyclases In Cocaine Sensitization. by Derek Paul Dirocco. Subscribe to alerts
Dopamine receptor antagonists fail to prevent induction of cocaine sensitization. ( PMID:9408916). Abstract; Citations List of citations in UKPMC which this record
Sensitization to cocaine refers to the behavioral model of cocaine addiction where the motor Key words: addiction; cocaine; craving; learning; sensitization
Cocaine Sensitization. High doses of cocaine produce a variety of behaviors, including increased activity and stereotyped behaviors like head bobs. Repeatedly
Intermittent administration of psychostimulants such as cocaine and amphetamine can result in behavioral sensitization, which is believed to model the onset of
Bradberry, C.W. Cocaine sensitization and dopamine mediation of cue effects in rodents, monkeys, and humans: Areas of agreement, disagreement, and
Title: The induction of behavioural sensitization is associated with cocaine- induced structural plasticity in the core (but not shell) of the nucleus accumbens
Melatonin, a pineal hormone and a potent free radical scavenger with neuroprotective actions, has been reported to act as an inhibitor of nitric
associated with cocaine and amphetamine sensitization, 8 hours after .. development of cocaine sensitization, but other receptor types and
Title: Effects Of Limbic Sensitization On Self-regard And Psychogenic Symptoms In Cocaine Addicts And Nonusers. Author: Alexander, Deanna. Issue date
BioInfoBank Library :: Ceftriaxone prevents the induction of cocaine sensitization and produces enduring attenuation of cue- and cocaine-primed reinstatement
Cocaine exposure significantly increases TDC enzyme activity in the brain in a time-dependent manner that parallels the develpment of sensitization.
Project Title: Neuroactive Steroids,Dopamine and Cocaine Sensitization behavioral habituation /sensitization, chemical structure function, cocaine, dopamine,
Neurotensin and cocaine sensitization. Neuropsychopharmacology . Author manuscript. Page /2 11. Given the link between cocaine s addictive properties and
Reversal of cocaine sensitization-induced behavioral sensitization normalizes GAD67 and GABAA receptor alpha2 subunit expression, and
To study interactions of D1 and D3 receptors in these functions, cocaine-induced locomotion, sensitization, reward and neurochemical responses were analyzed
BioInfoBank Library :: Effects of minocycline on cocaine sensitization and phosphorylation of GluR1 receptors in 5-lipoxygenase deficient mice. Minocycline
This dissertation first reports that cocaine sensitization promotes the acquisition of Lastly, cocaine sensitization and associated changes of dopamine neuron
Effect of cocaine sensitization prior to pregnancy on maternal care and aggression in the rat - Sciences Indexed Since 1998.
Cocaine Sensitization of Coronary Artery Contractions: Mechanism of Cocaine has been known for some time to sensitize responses of autonomic effector
Thus, since behavioural cocaine sensitization is characterized by tonically increased Thus, the behavioural modifications observed in cocaine-sensitized rats
Cocaine sensitization and reward are under the influence of circadian genes and rhythm. Authors: Abarca, Carolina; Albrecht, Urs; Spanagel, Rainer
Cocaine locomotor sensitization across strains . Locomotor activity for 30-minute sessions across eight days of conditioning. Saline treatment
The first cocaine injection induced a locomotor sensitization that was completely context-dependent, increased during the first week, and persisted 3 months
The present study was designed to find out whether 5-HT1B receptors located in subareas of the nucleus accumbens played a role in cocaine sensitization in
We also show the involvement of a subset of circadian genes in sensitization. Four of the five known circadian genes affect cocaine sensitization; only the gene
Infusion of Tat-GPR mimicked the phenotype of chronic cocaine-treated rats by manifesting sensitized locomotor behavior and drug seeking and by increasing
Dopamine Receptor Antagonists Fail to Prevent Induction of Cocaine Sensitization Francis J White Ph.D, Amit Joshi MD, Timothy E Koeltzow BA and Xiu-Ti Hu
This cocaine "sensitization" can be produced by a single exposure to cocaine Cocaine sensitization is believed by some workers to be involved in a variety of
RESULTS We used context-specific sensitization of cocaine-induced locomotor Subsequent cocaine-induced locomotor responses are robustly sensitized
RESULTS: Transient overexpression of GR during early life led to increased anxiety and cocaine sensitization, paralleling the phenotype of lifelong GR
Order from the British Library: Cortical Mechanisms of Cocaine Sensitization.
Context‐specific modulation of cocaine‐induced locomotor sensitization and ERK and CREB phosphorylation in the rat nucleus accumbensby Sam Golden
elevated cocaine sensitization profiles, and cocaine history differentially affected subsequent ioral sensitization to cocaine, and self-administration of amphet-
Additional groups of rats were treated similarly with saline or cocaine on days 1-3 and sacrificed or tested for locomotor sensitization on day 8. Consistent with
Contains details of Influences nitric oxide synthase inhibitors cocaine sensitization.
In the present study, we attempted to determine the role of DA D3 receptors in the expression phase of sensitization to cocaine in rats, using the selective ligands
Powerful demonstration that drug sensitization causes nucleus glutamate AMPA receptors to migrate to neuronal surface.
Neither ibotenic acid nor volkensin lesions of the nucleus accumbens shell affect the expression of cocaine sensitization. M S Todtenkopf, J R Stellar, R H
Sensitization of Arteries, Veins, and Small. Vessels to Norepinephrine After Cocaine. By Francois M. Abboud, M.D., John W. Eckstein, M.D.,. Ben G. Zimmerman
Behavioral Sensitization to Cocaine Is Associated with Increased AMPA Receptor Surface Expression in the Nucleus Accumbens
THE EXPRESSION OF COCAINE SENSITIZATION IN RATS. Ma³gorzata Filip the behavioral (i.e. sensitizing) effects of cocaine in rodents. Among DA re-
Increased acute cocaine sensitivity and decreased cocaine sensitization in GABA (A) receptor beta3 subunit knockout mice. Resnick A, Homanics GE, Jung BJ,
Abstract. Repeated intermittent cocaine treatment often results in behavioral sensitization or an augmented response to cocaine. Cocaine-induced behavioral
inhibition of cocaine sensitization by. 1-methyl-1 tivity of rats (Wistar) after a single cocaine (15 mg/kg, ip) dose and during cocaine sensitization (15 mg/kg, ip ).
Cocaine Rotational behavior Sensitization Reverse tolerance 6- Hydroxydopamine. THE repeated administration of psychomotor stimulant drugs produces a
Strain differences in the effects of adrenalectomy on the midbrain dopamine system: implication for behavioral sensitization to cocaine. Neuroscience. 2008 May
Indeed, the development of cocaine sensitization (mediated in the ventral tegmental area, VTA) can be prevented by NMDA receptor antagonists. Since, in
RATIONALE: Glutamatergic projection neurons in the medial prefrontal cortex ( mPFC) are hyperexcitable in cocaine-sensitized animals, resulting in increased
NE Modulation of VTA Excitation in Cocaine Sensitization,. RO1 NINCDS-NIDA Noradrenergic mechanisms in cocaine sensitization and epilepsy. 1989-2004
The EEG and Cocaine Sensitization. A Hypothesis. Kenneth R. Alper, M.D.. Received November 9, 1998; revised January 25, 1999; accepted February 8, 1999.
A full listing of Abstracts and Neural plasticity and addiction: integrin-linked kinase and cocaine behavioral sensitization.
Behavioral sensitization of motor activityamphetamine, cocaine, repeated injections of cocaine produce behavioral sensitization." "Acute
(2009) Chen et al. Neuroscience Letters. Read by researchers in: 100% Medicine. Growing evidence has pointed to an interaction between the tetracycline
Moreover, we show that ERα knock-out mice exhibit enhanced cocaine sensitization and conditioned place preference and an increase in Alk
Titre du document / Document title. Stimulus gated cocaine sensitization : Interoceptive dmg cue control of cocaine locomotor sensitization. Auteur(s) / Author(s)
Inhibition of cocaine sensitization by MK-801, a noncompetitive N-methyl-D- aspartate (NMDA) receptor antagonist: evaluation by ambulatory activity in mice.
Here we show that the mouse homologues of the Drosophila Per gene, mPer1 and mPer2, modulate cocaine sensitization and reward, two
How PDE4 inhibition affects cocaine-induced sensitization is unknown and was investigated in this thesis by measuring locomotor activity in mice. In the first set
cocaine (10mg/kg, i.p.) induced hyperlocomotor responses in wild-type and knockout mice and a chronic cocaine treatment produced a similar sensitization to
Cocaine-induced sensitization induces long-term neuroplastic changes in the striatum. Among these, extracellular signal-regulated kinase
The mesoaccumbens dopamine system is intricately involved in the locomotor stimulation produced by cocaine and sensitization of this effect
Women are more likely and take shorter time to become cocaine dependent after initial use of cocaine. Behavioral sensitization is an animal model that allows
Date Published, 2007 Apr 23. ISSN, 0031-9384. DOI, 10.1016/j.physbeh.2007.01 .010. Short Title, Cocaine sensitization in male quail temporal conditioning and
Repeated cocaine administration induces behavioral sensitization and modifications in the phosphorylation pattern of dopamine and cAMP-regulated
sion of behavioral sensitization. To evaluate the robustness of changes in G proteins induced by daily cocaine treatments capable of producing behavioral
Repeated%20exposure%20to%20cocaine%20often%20leads%20to% 20tolerance%20to%20effects%20on%20operant%20behavior%2C%20whereas %
by repeated cocaine administration, including behavioral sensitization to repeated initiation of cocaine sensitization incorporates the acute pharmacologi-
Cocaine Sensitization And Dopamine Transporter Regulation [Nancy Rutledge Zahniser, University Of Colorado Denver]: DESCRIPTION (provided by
Mice were subjected to a cocaine sensitization regimen (15.0 mg/kg cocaine on nine consecutive days followed by a 7.5 mg/kg cocaine
Here we review the contribution of 5-HT receptor subtypes to cocaine sensitization, discrimination, conditioned place preference, self-administration,
Behavioral sensitization following repeated intermittent cocaine administrations is thought to involve alterations in cocaine regulation of neural activity within the
Serotonin Involvement in Cocaine Sensitization: Clues. From Studies With Cocaine Analogs. John D. Elsworth, Jane R. Taylor, Peter Jatlow, and Robert H. Roth
The authors hypothesized that this LTP may underlie the sensitization of the locomotor response to cocaine that results from an injection of
Furthermore, we have evidence that this impairment in cocaine sensitization in Fragile X mice results from acute loss of FMRP in a
blocks cocaine sensitization in Drosophila melanogaster. H. Li*, S. Chaney*, M. Forte† and J. Hirsh*. Sensitization to repeated doses of psychostimulants is
In their studies, they sought to understand the effects of cocaine sensitization on the connections between two higher brain regions--the
Dopamine D1 receptor activation in the medial prefrontal cortex prevents the expression of cocaine sensitization. B A Sorg, N Li, W R Wu J Pharmacol Exp Ther
Behavioral sensitization induced by repeated cocaine administration is associated with long-term alterations in neurotransmission in the nucleus accumbens
Studies support the involvement of mPFC dopaminergic and glutamatergic systems in the development of cocaine sensitization. GABA is known to modulate
Sensitization, But Not Cocaine Sensitization, When Assessed by Ambulatory cocaine (10 mg kg-I), neither drug inhibited the cocaine sensitization. Mice given
The initiation of behavioral sensitization to cocaine and other psychomotor stimulants is thought to reflect N-methyl-D-aspartate receptor
sensitization, rats were given daily i.p. injections of 15 mg ⁄ kg of cocaine (or saline) for 8 psychomotor sensitization, or whether cocaine induces this form of
The results indicate that distinct adaptations in neural activation take place in cocaine-sensitized rats that have been drug-free for various lengths of time.
Contains details of Reversal cocaine sensitization-induced behavioral sensitization normalizes GAD67 GABAA receptor alpha 2 subunit expression, PKC zeta
The major hypotheses addressed in the first section of this dissertation are that the calcium/calmodulin (Ca2+/CaM)-stimulated adenylyl
Evidence for classical conditioning of cocaine's motor-activity effects and context- specific behavioral sensitization to cocaine was obtained, relative to
The repeated administration of cocaine produces enduring neuroadaptations that are associated with enhanced behavioral responsiveness to cocaine
2001) and antagonists block expression of cocaine sensitization (Pierce et al. 1998). Furthermore, corticotropin-releasing factor (CRF) systems in the amygdala
Nalbuphine Attenuates the Development of Behavioral Sensitization to Cocaine. Kathryn Cole. Davidson College. (Introduction submitted in place of annotated
SpringerImages - Cocaine and amphetamine sensitization facilitates habit formation. (a) Lister hooded rats initially received one daily IP injection of
Cocaine self-administration in rodents has been used widely as a preclinical model of cocaine use in humans. In laboratory animals, estradiol
The EEG and Cocaine Sensitization: A Hypothesis. Abstract. The author presents the hypothesis that reduced delta EEG power observed in cocaine withdrawal
While Ox1r has been implicated in cocaine sensitization (Borgland et al., 2006), the role of Ox1r in cocaine CPP has not yet been reported. It has been
dence for cocaine-induced sensitization was seen when examining locomotion preweanlings can exhibit cocaine sensitization, partic- ularly in terms of
Cocaine sensitization and dopamine mediation of cue effects in rodents, monkeys, and humans: areas of agreement, disagreement, and
We demonstrated that the expression of locomotor sensitization, induced by four cocaine injections (15 mg/kg, i.p.) every other day and a
In the nucleus, DNA wraps around histone proteins, which pack the DNA and makes it less accessible for transcription. Many transcriptional
The impact of stress, cocaine or morphine sensitization on cocaine self- sensitization to social-defeat stress or cocaine intensifies cocaine intake during a
Expression of cocaine sensitization: regulation by the medial prefrontal cortex. Prasad BM, Hochstatter T, Sorg BA. Program in Neuroscience, Department of
Many rodent models of cocaine sensitization use intermittent high doses of cocaine pretreatment foll.
The goal of this work is to elucidate the role of alpha adrenergic receptors at the VTA and RFC in the development and expression of cocaine sensitization.
The Alzheimer Research Forum, a dynamic online scientific knowledge base, reports on the latest Alzheimer's scientific research and develops databases of
Cocaine sensitization is produced by repeated exposure to the drug and is thought to reflect cocaine-sensitized animals acquire cocaine self- administration
the magnitude of the S/I ratio for cocaine-sensitized rats was positively drug- seeking responses are more effectively triggered in cocaine-sensitized rats
Sodium appetite and cocaine sensitization share similar mechanisms. Martin Javier Acerbo1 and Alan Kim Johnson1,2. 1 Psychology 2 Pharmacology, and
We used CCR2 knockout mice (CCR2−/−) and studied two crucial steps in cocaine sensitization: locomotor activity in sensitized mice and ERK activation in the
tal treatment groups subjected to the same cocaine sensitization regimen The locomotor sensitization to repeated cocaine ad- ministration
mini-pump (0.1 mg/kg/day) during the induction of cocaine sensitization and, after 2 or sensitized to cocaine received dizocilpine by infusion and daily cocaine
Deletion of Go2α abolishes cocaine-induced behavioral sensitization by disturbing the striatal dopamine system. Brunk, Irene,; Blex, Christian,; Sanchis- Segura,
G protein involvement in cocaine sensitization by Caryn Diane Striplin, 1994 edition, in English.
'Cocaine sensitization and craving: differing roles for dopamine and glutamate in the nucleus accumbens.' on BiomedExperts. Find the right expert or researcher
RESULTS: Transient overexpression of GR during early life led to increased anxiety and cocaine sensitization, paralleling the phenotype of
Kubera M. The effect of cocaine sensitization on mouse immunoreactivity. Eur J Pharmacol 483:309 (2004)
Abstract: Recently, we reported that minocycline reduces the ability of cocaine to develop locomotor sensitization in mice (Neurosci. Lett.
This dissertation is trying to further characterize cocaine sensitization in females and to examine the role of ascending midbrain dopaminergic
Wei Zhao, Jill Becker (2006) Cocaine sensitization fails to enhance extracellular dopamine in striatum in both male and female rats. Society for Neuroscience
論文：Cocaine sensitization and craving: differing roles[Journal of addictive diseases] - Pubmed Result(ATGCchecker)の詳細情報です。フルテキスト情報、関連
論文：Cocaine conditioning and cocaine sensitization: wh[Behavioural brain research] - Pubmed Result(ATGCchecker)の詳細情報です。フルテキスト情報、関連
Reports by Lindblom3 and Halsey4 indicated a similar cocaine sensitization of the small bowel to the inhibitory action of epinephrine. We, however, have made
condition of cocaine sensitization as an inducing condition for anhedonia in rats. hypothesized that cocaine-sensitized rats might reveal deficits in palatable
Cocaine sensitization (view protocol), Drug Abuse. Cocaine-influenced activity ( view protocol), Drug Abuse, Movement/Neuromuscular Function. MUTANT LINE
A role for the calcium/calmodulin-stimulated adenylyl cyclases in cocaine sensitization. - Derek Paul,Daniel R. - Doctoral Thesis / Dissertation - Neurobiology
(2002) Beyer, Steketee. Cerebral Cortex. Read by researchers in: 100% Biological Sciences. Repeated administration of cocaine progressively increases
Long-term blockade of the expression of cocaine sensitization by ondansetron, a 5-HT3 receptor antagonist. Authors: King G.R.; Xiong Z.;
These findings indicate unexpected roles for these genes in regulating cocaine sensitization and indicate that they function as regulators of
A similar challenge with 10 mg/kg of SP after cocaine sensitization did not Similar to that in naïve rats, cocaine's effect on the EPSCs in these sensitized rats
SpringerImages - Effect of early postnatal sibling deprivation on cocaine sensitization in female (a) and male (b) adult rats. All the female and male adult rats
Effect of cocaine sensitization on α1-adrenoceptors in brain regions of the rat: an autoradiographic analysis. Irena Nalepa1, Tadeusz Witarski1, Marta
The Involvement Of Tyramine In Cocaine Sensitization [Shannon L. Hardie, University Of Virginia Charlottesville]: Exposure to psychostimulants such as
This study investigated the long-lasting condition of cocaine sensitization as an Thus, since behavioural cocaine sensitization is characterized by tonically
Investigations using the fruit fly Drosophila melanogaster have shown that the circadian clock gene period (Per) can influence behavioral responses to cocaine.
(Received February I , 1993). This research determined whether sensitization (or tolerance) to the behavioral effects of cocaine in rat pups would occur following
In order to examine the effects of isoflurane on cocaine-sensitization, we administered cocaine (15mg/kg i.p) or saline to adult male and female
To study the developmental contributions to addictive behaviors, we measured behavioral responses in adult offspring to a cocaine sensitization paradigm
Scholars Portal - Development of cocaine sensitization before pregnancy affects subsequent maternal retrieval of pups and prefrontal cortical activity during
The effect of cocaine sensitization on mouse immunoreactivity. View Full Text ( Elsevier ScienceDirect user account required). Author(s). Kubera, M., Filip, M.,
Cocaine sensitization prevents the hypolocomotor effects of high but not low doses of PD 128907. Author(s). Prinssen, E.P.M., Koek, W., Kleven, M.S.,. Journal
Doc Info Zoom Zoom In Zoom Out. First Page Previous Page Next Page. of 12. /lp /wiley/serotonin-involvement-in-cocaine-sensitization-clues-from-studies-with-
(1999) Andretic et al. Science. Read by researchers in: 75% Biological Sciences, 25% Medicine. The circadian clock consists of a feedback loop in which clock
Effects of multiple administrations of cocaine and subsequent cocaine withdrawal on the activity of nitric oxide synthase (NOS) in brain regions and spinal cord of
EBSCOhost serves thousands of libraries with premium essays, articles and other content including Enhanced morphine- and cocaine-induced behavioral
expression of sensitization to cocaine and methamphet- amine (METH) in . on the induction and expression of sensitization of cocaine, each of the five groups
Expression profiling of basal gene expression in microdissected mouse brain regions during initiation of cocaine sensitization shows striking patterns of gene
Abstract In the United States, one-third of infected individuals contracted Human Immunodeficiency Virus-1 (HIV-1) via injecting drugs with contaminated
Scholars Portal - Cocaine sensitization prevents the hypolocomotor effects of high but not low doses of PD 128907.
To investigate whether the same regimen of methadone exposure could prevent the incubation of cocaine sensitization and related alterations in gene
Involvement of serine/threonine protein phosphatases sensitive to okadaic acid in restraint stress-induced hyperlocomotion in cocaine-sensitized mice. Maeda
The present study was designed to further examine the involvement of mPFC dopamine D(2) receptors in cocaine sensitization. OBJECTIVES:
These findings suggest that cocaine sensitization is rela- tively persistent, but . of cocaine sensitization (Post et al., 1992), and of enhanced basal and cocaine-
UK PubMed Central (UKPMC) is an archive of life sciences journal literature.
The expanding set of genomics tools available for inbred mouse strains has renewed interest in phenotyping larger sets of strains. The present study aims to
Early-Life Forebrain Glucocorticoid Receptor Overexpression Increases Anxiety Behavior and Cocaine Sensitization. Author(s): Wei, Qiang
Varying the dose and length of cocaine did not affect sensitization, OVX rats did not become sensitized to cocaine. However, strengthening drug-context
To test the extent of sensitization, cocaine was administered.
A full listing of Abstracts and Ondansetron given in the acute withdrawal from a repeated cocaine sensitization dosing regimen reverses the expression of
The requirement for differential tolerance at D3 vs D1 and D2 receptors may explain the observed development of sensitization following application of cocaine,
Chen Q. Integrin-Linked Kinase Is Involved in Cocaine Sensitization by Regulating PSD-95 and Synapsin I Expression and GluR1 Ser(845) Phosphorylation.
The present experiments were performed in order to study whether a similar selective inhibition of expression of associative sensitization to cocaine can be
The cocaine regimen induced behavioral and locomotor sensitization on day 10 of Keywords: Cocaine; Sensitization; Self-administration; Withdrawal;
(2007) investigated the effects of cocaine sensitization on decision making in rats and showed that drug Cocaine sensitization and the Actor/Critic model
sensitization mature after those subserving short-term cocaine sensitization obtained with intermittent injec- tions (daily injections at 4, 5, 6, and 7 days of age :
Cocaine sensitization does not alter SP effects on locomotion or excitatory synaptic transmission in the NAc of rats. Kombian SB
injection of cocaine. Only AMPA/kainate receptor blockade prevented the development of behavioural sensitization to cocaine. These data indicate that the
VTA OFQ/N administration on cocaine sensitization was ioral sensitization to cocaine could represent pharma- effective in blocking cocaine sensitization.
Requirement of circadian genes for cocaine sensitization in Drosophila Sensitization to repeated cocaine exposures, a phenomenon also seen in humans
Sensitization to cocaine refers to the behavioral model of cocaine addiction the motor stimulant effect of cocaine is augmented for months after discontinuing a
These treatments fail to alter acute behavioral responses to cocaine, and they do not block the expression of cocaine sensitization when it is established before
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